PROLACTIN - ITS ROLE IN THE DEVELOPMENT OF MAMMARY-TUMORS

被引：12

作者：

NAGASAWA, H

机构：

[1] Pharmacology Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104

来源：

MEDICAL HYPOTHESES | 1979年 / 5卷 / 10期

关键词：

D O I：

10.1016/0306-9877(79)90027-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Experimentally, it has been found that the rate of DNA synthesis of normal mammary glands which is a limiting factor for mammary tumourigenesis is largely dependent upon the circulating level of prolactin. Based on these results, one of the roles of prolactin in the development of mammary tumours is hypothesized to create mammary gland conditions favourable for the action of carcinogens through its stimulation of the rate of mammary gland DNA synthesis, a measure of the frequency of mammary gland cell division. © 1979.

引用

页码：1117 / 1121

页数：5

共 11 条

[1]

MUHLBOCK O, 1959, CANCER RES, V19, P402

[2]

NAGASAWA H, 1976, CANCER RES, V36, P2223

[3] PROLACTIN AND HUMAN BREAST-CANCER - REVIEW [J].