IDENTIFICATION OF INDUCIBLE DAMAGE-RECOGNITION PROTEINS THAT ARE OVEREXPRESSED IN HELA-CELLS RESISTANT TO CIS-DIAMMINEDICHLOROPLATINUM(II)

Two cis-diamminedichloroplatinum(II) (cisplatin)-inducible proteins [b130 (approximately 130 kDa) and b95 (approximately kDa)] in HeLa cells that recognize both the cisplatin-modified and u.v.-modified DNA were identified in this study. These damage-recognition proteins were overexpressed in cisplatin-resistant HeLa cells. The results suggest that the damage-recognition proteins are regulated in the cells in response to DNA damage, and they may be important for DNA repair and probably the emergence of cisplatin resistance.