RETINOIC ACID AND TRANSFORMING GROWTH-FACTOR-BETA DIFFERENTIALLY INHIBIT PLATELET-DERIVED-GROWTH-FACTOR-INDUCED ITO-CELL ACTIVATION

被引：62

作者：

DAVIS, BH ^{[1
]}

RAPP, UR ^{[1
]}

DAVIDSON, NO ^{[1
]}

机构：

[1] NCI,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21701

来源：

BIOCHEMICAL JOURNAL | 1991年 / 278卷

关键词：

D O I：

10.1042/bj2780043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sinusoidal Ito cells (stellate or fat-storing cells) undergo excessive cellular proliferation before the establishment and progression of hepatic fibrosis and cirrhosis. Retinoic acid and transforming growth factor-beta (TGF-beta) both inhibit Ito-cell [H-3]thymidine incorporation in serum-containing media. Serum-induced mitogenicity was dependent on platelet-derived growth factor (PDGF). Additionally, pre-treatment of Ito cells with retinoic acid and TGF-beta blocked PDGF-induced cell proliferation. TGF-beta, but not retinoic acid, diminished PDGF-receptor and smooth-muscle alpha-actin abundance.

引用

页码：43 / 47

页数：5

共 34 条

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