PREOVULATORY EFFECTS OF THE PROGESTERONE ANTAGONIST MIFEPRISTONE (RU486) IN MICE

被引：69

作者：

LOUTRADIS, D ^{[1
]}

BLETSA, R ^{[1
]}

ARAVANTINOS, L ^{[1
]}

KALLIANIDIS, K ^{[1
]}

MICHALAS, S ^{[1
]}

PSYCHOYOS, A ^{[1
]}

机构：

[1] ALEXANDRA MATERN HOSP,ATHENS MED SCH,DEPT OBSTET & GYNAECOL 1,GR-11528 ATHENS,GREECE

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 09期

关键词：

MIFEPRISTONE (RU486); OVULATION; FOLLICULOGENESIS; OOCYTE; PREIMPLANTATION EMBRYO;

D O I：

10.1093/oxfordjournals.humrep.a137519

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The progesterone antagonist mifepristone (RU486), was given in mice once on different days of pregnant mare's serum gonadotrophin-human chorionic gonadotrophin (PMSG-HCG) treatment and its action upon the induction of ovulation studied. RU486 administered on the day after PMSG significantly reduced the ovulation rate. Ovulation was completely inhibited when the progesterone antagonist was given simultaneously with HCG, but RU486 administered 4 h after HCG treatment remained ineffective. The development of two-cell zygotes harvested on day 2 post-coitum from mice treated with RU486 on the day after the PMSG treatment was followed in vitro and showed a significant decrease in the number of embryos developing to blastocysts. These results favour the involvement of progesterone in the ovulation process, indicating a direct effect of this hormone at the ovarian level via a progesterone receptor-mediated action.

引用

页码：1238 / 1240

页数：3

共 10 条

[1]

Baulieu E.E., Contragestkm and other clinical applications of RU486, an antiprogesterone at the receptor, Science, 245, pp. 1351-1357, (1989)

[2]

Danforth D.R., Dubois C., Ulmann A., Baulieu E.E., Hodgen G.D., Contraceptive potential of RU486 by ovulation inhibition: ID, Preliminary Observations on Once Weekly Oral Administration. Contraception, 40, (1989)

[3]

Kekkonen R., Alfthan H., Haukkamaa M., Heikinheimo O., Luuk-Kainen T., Lahteenmaki P., Interference with ovulation by sequential treatment with the antipnogesterone RU486 and synthetic progestin, Fertil. Steril, 53, (1990)

[4]

Lipner H., Mechanism of mammalian ovulation, The Physiology of Reproduction, 1, (1988)

[5]

Loutradis D., John D., Kiessling A.A., Hypoxanthine causes a 2-cell block in random bred mouse embryos. Biol, Reprod., 37, pp. 311-316, (1987)

[6]

Luukkainen T., Heikinheimo O., Haukkamaa M., Lahteenmaki P., Inhibition of folliculogenesis and ovulation by the antiprogesterone RU486. Fertil, Steril., 49, pp. 961-963

[7]

Psychoyos A., The future of antiprogestins. Proceedings of the First Congress of the European Society of Contraception, Advances in Contraception, (1990)

[8]

Swahn M.L., Johannisson E., Daniore V., De La Torre B., Bygdeman M., The effect of RU486 administered during the proliferative and secretory phase of the cycle on the bleeding pattern, Hormonal Parameters and the Endometrium. Hum. Reprod, 3, pp. 915-921, (1988)

[9]

Van Uem J.F., Hsiu J., Chillik C.F., Danforth D.R., Ulmann A., Baulieu E.E., Hodgen G.D., Contraceptive potential of RU486 by ovulation inhibition: I. Pituitary versus ovarian action with blockade of estrogen-induced endometrial proliferation, Contracep Tion, 40, pp. 171-184, (1989)

[10]

Wolf J.P., Danforth D.R., Ulmann A., Baulieu E.E., Hodgen G.D., Contraceptive potential of RU486 by ovulation inhibition: 2. Suppression of pituitary gonadotropin secretion in vitro, Contracep Tion, 40, (1988)

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