ENANTIOSELECTIVE ROUTES TOWARD 1-BETA-METHYLCARBAPENEMS FROM CHIRAL AZIRIDINES

被引：56

作者：

TANNER, D

HE, HM

机构：

[1] Department of Organic Chemistry, University of Uppsala, S-751 21 Uppsala

来源：

TETRAHEDRON | 1992年 / 48卷 / 29期

关键词：

1-BETA-METHYLCARBAPENEMS; CHIRAL AZIRIDINES; REGIOSELECTIVE RING-OPENING;

D O I：

10.1016/S0040-4020(01)89856-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper describes two enantioselective aziridine-based routes toward 1-beta-methylthienamycin, 2, and related carbapenems, the key steps being completely regioselective ring-opening reactions of the chiral aziridines 7 and 10 with AlMe3.

引用

页码：6079 / 6086

页数：8

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