TEMPERATURE EFFECTS IN ASYMMETRIC DIHYDROXYLATION - EVIDENCE FOR A STEPWISE MECHANISM

被引：138

作者：

GOBEL, T

SHARPLESS, KB

机构：

[1] Department of Chemistry, Scripps Research Institute, La Jolla, California, 92307

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 09期

关键词：

D O I：

10.1002/anie.199313291

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

For more than 50 years, the accepted opinion was that the dihydroxylation of olefins with OsO4 proceeded by a concerted mechanism [Eq. (a)]. However, if the influence of the reaction temperature on the enantiomeric excesses in asymmetric dihydroxylations is studied, Eyring plots are obtained with inversion points, which is consistent with a stepwise mechanism. (Figure Presented.) Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1329 / 1331

页数：3

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