STEADY-STATE TRANSCRIPT LEVELS OF THE TYPE-II HEXOKINASE AND TYPE-1 GLUCOSE-TRANSPORTER IN HUMAN TUMOR-CELL LINES

被引：55

作者：

SHINOHARA, Y ^{[1
]}

YAMAMOTO, K ^{[1
]}

KOGURE, K ^{[1
]}

ICHIHARA, J ^{[1
]}

TERADA, H ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,FAC PHARMACEUT SCI,TOKUSHIMA 770,JAPAN

来源：

CANCER LETTERS | 1994年 / 82卷 / 01期

关键词：

TYPE II HEXOKINASE; TYPE 1 GLUCOSE TRANSPORTER NORTHERN BLOTTING; HUMAN TUMOR CELL LINES;

D O I：

10.1016/0304-3835(94)90142-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The steady state transcript levels of two hexokinase isozymes and type 1 glucose transporter in human tumor cell lines were analyzed. In HepG2 cells, both type II hexokinase and type 1 glucose transporter were highly expressed. However, in cell lines A431 and HeLa, in which the expression level of type 1 glucose transporter was lower than that in HepG2 cells, the amount of type II hexokinase transcript was almost negligible.

引用

页码：27 / 32

页数：6

共 24 条

[1]

ANDREONE TL, 1989, J BIOL CHEM, V264, P363

[2] TRANSFORMATION OF RAT FIBROBLASTS BY FSV RAPIDLY INCREASES GLUCOSE TRANSPORTER GENE-TRANSCRIPTION [J].

BIRNBAUM, MJ ;

HASPEL, HC ;

ROSEN, OM .

SCIENCE, 1987, 235 (4795) :1495-1498

[3]

BUSTAMANTE E, 1981, J BIOL CHEM, V256, P8699

[4] HIGH AEROBIC GLYCOLYSIS OF RAT HEPATOMA-CELLS IN CULTURE - ROLE OF MITOCHONDRIAL HEXOKINASE - (L-LACTIC ACID-D-GLUCOSE-D-GALACTOSE-LIVER-NEOPLASIA) [J].

BUSTAMANTE, E ;

PEDERSEN, PL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (09) :3735-3739

[5]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[6] ELEVATED LEVELS OF GLUCOSE-TRANSPORT AND TRANSPORTER MESSENGER-RNA ARE INDUCED BY RAS OR SRC ONCOGENES [J].

FLIER, JS ;

MUECKLER, MM ;

USHER, P ;

LODISH, HF .

SCIENCE, 1987, 235 (4795) :1492-1495

[7] ISOENZYME SHIFT FROM GLUCOKINASE TO HEXOKINASE IS NOT AN EARLY BUT A LATE EVENT IN HEPATOCARCINOGENESIS [J].

KLIMEK, F ;

BANNASCH, P .

CARCINOGENESIS, 1993, 14 (09) :1857-1861

[8]

KOGURE K, 1993, J BIOL CHEM, V268, P8422

[9] SEQUENCE AND STRUCTURE OF A HUMAN GLUCOSE TRANSPORTER [J].

MUECKLER, M ;

CARUSO, C ;

BALDWIN, SA ;

PANICO, M ;

BLENCH, I ;

MORRIS, HR ;

ALLARD, WJ ;

LIENHARD, GE ;

LODISH, HF .

SCIENCE, 1985, 229 (4717) :941-945

[10]

MURAKAMI T, 1992, J BIOL CHEM, V267, P9300

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