INDUCTION OF METAPHASE ARREST IN DROSOPHILA OOCYTES BY CHIASMA-BASED KINETOCHORE TENSION

被引：50

作者：

JANG, JK ^{[1
]}

MESSINA, L ^{[1
]}

ERDMAN, MB ^{[1
]}

ARBEL, T ^{[1
]}

HAWLEY, RS ^{[1
]}

机构：

[1] UNIV CALIF DAVIS, DEPT GENET, MOLEC & CELLULAR BIOL SECT, DAVIS, CA 95616 USA

来源：

SCIENCE | 1995年 / 268卷 / 5219期

关键词：

D O I：

10.1126/science.7604267

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In normal Drosophila melanogaster oocytes, meiosis arrests at metaphase I and resumes after oocyte passage through the oviduct. Thus, metaphase arrest defines a control point in the meiotic cell cycle. Metaphase arrest only occurs in oocytes that have undergone at least one meiotic exchange. Here it Is shown that crossovers between homologs attached to the same centromere do not induce metaphase arrest. Hence, exchanges induce metaphase arrest only when they physically conjoin two separate kinetochores. Thus, the signal that mediates metaphase arrest is not the exchange event per se but the resulting tension on homologous kinetochores.

引用

页码：1917 / 1919

页数：3

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