ATHEROGENIC LIPOPROTEINS AND RELEASE OF PLASMINOGEN-ACTIVATOR INHIBITOR-1 (PAI-1) BY ENDOTHELIAL-CELLS

被引：40

作者：

MUSSONI, L ^{[1
]}

MADERNA, P ^{[1
]}

CAMERA, M ^{[1
]}

BERNINI, F ^{[1
]}

SIRONI, L ^{[1
]}

SIRTORI, M ^{[1
]}

TREMOLI, E ^{[1
]}

机构：

[1] UNIV MILAN,E GROSSI PAOLETTI CTR,I-20122 MILAN,ITALY

来源：

FIBRINOLYSIS | 1990年 / 4卷

关键词：

Atherogenic lipoproteins; Endothelial cells; Plasminogen activator inhibitor;

D O I：

10.1016/0268-9499(90)90367-S

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties. © 1990.

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页码：79 / 81

页数：3

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