COMPARATIVE PATHOLOGY OF OVARIAN NEOPLASMS .2. GONADAL STROMAL TUMORS OF BOVINE SPECIES

The clinical and pathologic features of 26 neoplasms derived from gonadal stroma of hovine species were analyzed. Two types were identified-1 a typical granulosa tumor, the other having a Sertoli pattern. The 13 granulosa tumors occurred in adult animals, 2 of which exhibited nymphomania. Nine of the 13 had metastasized by the time of discovery. The Sertoli type of tumor also occurred in adult animals. Estrinizing effects were more common in these, as the endometrium had varying degrees of hyperplasia or thickening in 7 instances, and 1 animal had persistent estrus. None had spread beyond the ovary. The Sertoli type was thought to be more closely related to granulosa tumors than arrhenoblastomas because it was associated with estrinizing rather than virilizing effect, all of them lacked Leydig cells, some had overlapping microscopic patterns with granulosa tumors. and a Sertoli arrangement could be identified that was similar to areas in early graafian follicles and atretic follicles. They merit separation from granulosa tumors because of their distinctive histological pattern and because of their much more benign clinical behavior. © 1969, American College of Veterinary Pathologists. All rights reserved.