SYNTHESIS OF OPTICALLY-ACTIVE SILYL PROTECTED CYANOHYDRINS

被引：106

作者：

BRUSSEE, J ^{[1
]}

LOOS, WT ^{[1
]}

KRUSE, CG ^{[1
]}

VANDERGEN, A ^{[1
]}

机构：

[1] DUPHAR BV,1380 AA WEESP,NETHERLANDS

来源：

TETRAHEDRON | 1990年 / 46卷 / 03期

关键词：

D O I：

10.1016/S0040-4020(01)81377-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mandelonitrile lyase as present in a crude extract of almond flour has been tested for the synthesis of several chiral cyanohydrins. Silylated cyanohydrins of benzaldehyde, 4-methoxybenzaldehyde, piperonal, 5-methylfurfural, butyraldehyde and crotonaldehyde were obtained in good yield and high enantiomeric excess (93%) after treatment with silyl chlorides and imidazole in DMF. © 1990.

引用

页码：979 / 986

页数：8

共 18 条

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