MOLECULAR GENETIC-BASIS OF THE HISTO-BLOOD GROUP ABO SYSTEM

被引：872

作者：

YAMAMOTO, F ^{[1
]}

CLAUSEN, H ^{[1
]}

WHITE, T ^{[1
]}

MARKEN, J ^{[1
]}

HAKOMORI, SI ^{[1
]}

机构：

[1] UNIV WASHINGTON, SEATTLE, WA 98119 USA

来源：

NATURE | 1990年 / 345卷 / 6272期

关键词：

D O I：

10.1038/345229a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The histo-blood group ABO, the major human alloantigen system, involves three carbohydrate antigens (ABH). A, B and AB individuals express glycosyltransferase activities converting the H antigen into A or B antigens, whereas 0(H) individuals lack such activity. Here we present a molecular basis for the ABO genotypes. The A and B genes differ in a few single-base substitutions, changing four amino-acid residues that may cause differences in A and B transferase specificity. A critical single-base deletion was found in the 0 gene, which results in an entirely different, inactive protein incapable of modifying the H antigen. © 1990 Nature Publishing Group.

引用

页码：229 / 233

页数：5

共 36 条

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