FURTHER CHARACTERIZATION OF BORDERLINE METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS AND ANALYSIS OF PENICILLIN-BINDING PROTEINS

被引：57

作者：

MONTANARI, MP

TONIN, E

BIAVASCO, F

VARALDO, PE

机构：

[1] UNIV ANCONA,SCH MED,INST MICROBIOL,I-60131 ANCONA,ITALY

[2] UNIV PADUA,SCH MED,I-35121 PADUA,ITALY

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 05期

关键词：

D O I：

10.1128/AAC.34.5.911

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Eighty-nine Staphylococcus aureus strains were grouped according to their susceptibility or resistance to methicillin and oxacillin. The role of β-lactamase in borderline methicillin resistance was confirmed by tests with β-lactamase inhibitors, particularly when salt-supplemented medium was used. A penicillin-binding protein assay indicated that borderline methicillin-resistant S. aureus strains do not produce PBP 2a.

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页码：911 / 913

页数：3

相关论文

共 15 条

[1] EFFECT OF NACL AND NAFCILLIN ON PENICILLIN-BINDING PROTEIN-2A AND HETEROGENEOUS EXPRESSION OF METHICILLIN RESISTANCE IN STAPHYLOCOCCUS-AUREUS [J].

CHAMBERS, HF ;

HACKBARTH, CJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (12) :1982-1988

[2] INCREASED AMOUNTS OF A NOVEL PENICILLIN-BINDING PROTEIN IN A STRAIN OF METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS EXPOSED TO NAFCILLIN [J].

CHAMBERS, HF ;

HARTMAN, BJ ;

TOMASZ, A .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (01) :325-331

[3] PENICILLIN-BINDING PROTEINS AND THE INTRINSIC RESISTANCE TO BETA-LACTAMS IN GRAM-POSITIVE COCCI [J].

FONTANA, R .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1985, 16 (04) :412-416

[4] LOW-AFFINITY PENICILLIN-BINDING PROTEIN ASSOCIATED WITH BETA-LACTAM RESISTANCE IN STAPHYLOCOCCUS-AUREUS [J].

HARTMAN, BJ ;

TOMASZ, A .

JOURNAL OF BACTERIOLOGY, 1984, 158 (02) :513-516

[5] EXPRESSION OF METHICILLIN RESISTANCE IN HETEROGENEOUS STRAINS OF STAPHYLOCOCCUS-AUREUS [J].

HARTMAN, BJ ;

TOMASZ, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 29 (01) :85-92

[6] THE ROLE OF BETA-LACTAMASE IN STAPHYLOCOCCAL RESISTANCE TO PENICILLINASE-RESISTANT PENICILLINS AND CEPHALOSPORINS [J].

MCDOUGAL, LK ;

THORNSBERRY, C .

JOURNAL OF CLINICAL MICROBIOLOGY, 1986, 23 (05) :832-839

[7] REGULATION OF PENICILLIN-BINDING PROTEIN-ACTIVITY - DESCRIPTION OF A METHICILLIN-INDUCIBLE PENICILLIN-BINDING PROTEIN IN STAPHYLOCOCCUS-AUREUS [J].

ROSSI, L ;

TONIN, E ;

CHENG, YR ;

FONTANA, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 27 (05) :828-831

[8]

SCHOENKNECHT FD, 1985, MANUAL CLIN MICROBIO, P1000

[9]

THORNSBERRY C, 1986, METHICILLIN RESISTAN, P7

[10] BETA-LACTAM-SPECIFIC RESISTANT MUTANTS OF STAPHYLOCOCCUS-AUREUS [J].

TONIN, E ;

TOMASZ, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (04) :577-583