ONCOGENE EXPRESSION IN CERVICAL INTRAEPITHELIAL NEOPLASIA AND INVASIVE CANCER OF CERVIX

被引：67

作者：

PINION, SB

KENNEDY, JH

MILLER, RW

MACLEAN, AB

机构：

[1] WESTERN INFIRM & ASSOCIATED HOSP,DEPT GYNAECOL,GLASGOW G11 6NT,SCOTLAND

[2] UNIV STRATHCLYDE,DEPT BIOMED INSTRUMENTAT,GLASGOW G1 1XW,SCOTLAND

[3] GLASGOW ROYAL INFIRM,DEPT GYNAECOL,GLASGOW G4 0SF,SCOTLAND

来源：

LANCET | 1991年 / 337卷 / 8745期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0140-6736(91)92518-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Expression of the oncogenes Ha-RAS, c-MYC, and ERB-2 was investigated with an automated image analysis system in 12 specimens of normal cervix, 10 of cervical intraepithelial neoplasia (CIN) grade 1, 24 of CIN 3, and 10 of invasive cancer of the cervix. There was amplification of all three oncogenes in CIN 3 and invasive cancer compared with normal cervix and CIN 1. The difference was most pronounced with an antibody to the RAS p21 protein, with no overlap between CIN 3 and the normal range. This method might be useful in screening for cervical neoplasia, and for the determination of which CIN lesions require treatment.

引用

页码：819 / 820

页数：2

共 11 条

[1] SEARCH FOR HUMAN PAPILLOMAVIRUS, HERPES-SIMPLEX VIRUS AND C-MYC ONCOGENE IN HUMAN GENITAL TUMORS [J].