RNA LEVELS OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR SUBUNITS ARE DIFFERENTIALLY REGULATED IN AXOTOMIZED FACIAL MOTONEURONS - AN INSITU HYBRIDIZATION STUDY

被引：27

作者：

SENBA, E ^{[1
]}

SIMMONS, DM ^{[1
]}

WADA, E ^{[1
]}

WADA, K ^{[1
]}

SWANSON, LW ^{[1
]}

机构：

[1] SALK INST BIOL STUDIES,HOWARD HUGHS MED INST,LA JOLLA,CA 92037

来源：

MOLECULAR BRAIN RESEARCH | 1990年 / 8卷 / 04期

关键词：

Facial nerve transection; Neuronal nicotinic ACh receptor; Rat; α3; Subunit; β2;

D O I：

10.1016/0169-328X(90)90049-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In situ hybridization histochemistry using complementary RNA probes revealed that α3 and β2 neuronal nicotinic acetylcholine receptor subunit mRNAs were expressed in 12% and 40% of facial motoneurons of the rat, respectively. The α3 subunit mRNA signals disappeared in response to axotomy, whereas the β2 subunit mRNA signal was remarkably enhanced, suggesting that mRNA levels of receptor subunits are differentially regulated in axotomized motoneurons. © 1990.

引用

页码：349 / 353

页数：5

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