PREPARATION AND EVALUATION OF SOME HYDROPHILIC PHENYLACETYLPIPERAZINES AS PERIPHERALLY SELECTIVE KAPPA-OPIOID RECEPTOR AGONISTS

被引：6

作者：

BIRCH, PJ

HAYES, AG

JOHNSON, MR

LEA, TA

MURRAY, PJ

ROGERS, H

SCOPES, DIC

机构：

[1] GLAXO GRP RES LTD,DEPT MED CHEM,WARE SG12 0DP,HERTS,ENGLAND

[2] GLAXO GRP RES LTD,DEPT NEUROPHARMACOL,WARE SG12 0DP,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)80229-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of hydrophilic phenylacetylpiperazines as potential peripherally selective kappa-opioid receptor agonists is described. Several compounds were potent kappa-agonists in vitro and one, the sulphone (18), showed significant peripheral selectivity in vivo.

引用

收藏

页码：1275 / 1278

页数：4

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