EFFECT OF BILATERAL DENERVATION OF THE IMMATURE RAT TESTIS ON TESTICULAR GONADOTROPIN RECEPTORS AND INVITRO ANDROGEN PRODUCTION

被引：34

作者：

CAMPOS, MB ^{[1
]}

CHIOCCHIO, SR ^{[1
]}

CALANDRA, RS ^{[1
]}

RITTA, MN ^{[1
]}

机构：

[1] INST NEUROBIOL,BUENOS AIRES,ARGENTINA

来源：

NEUROENDOCRINOLOGY | 1993年 / 57卷 / 02期

关键词：

TESTICULAR DENERVATION; GONADOTROPIN RECEPTORS; ANDROGEN PRODUCTION; TESTIS;

D O I：

10.1159/000126359

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have studied the effect of superior spermatic nerve (SSN) section on testicular gonadotropin receptors and in vitro androgen production by immature rat testis. Bilateral testicular denervation had no effect on testicular weight, serum androgens, LH, FSH and PRL levels. Denervation resulted in a significant inhibition of hCG stimulated in vitro androgen production. A reduction in the number of testicular LH receptors was observed after SSN section, while FSH binding sites remained unchanged. These results indicate that the number of LH receptors and testicular steroidogenic response to hCG are influenced by nerves reaching the testis.

引用

页码：189 / 194

页数：6

共 31 条

[1]

ANAKWE OO, 1984, BIOL REPROD, V30, P1142, DOI 10.1095/biolreprod30.5.1142

[2] CATECHOLAMINE STIMULATION OF ANDROGEN PRODUCTION BY RAT LEYDIG-CELLS - INTERACTIONS WITH LUTEINIZING-HORMONE AND LUTEINIZING-HORMONE-RELEASING HORMONE [J].