PLASMA AND JEJUNAL GLUTAMINE LEVELS AFTER EXTENSIVE SMALL-BOWEL RESECTION IN DOGS

被引：8

作者：

ASTRE, C ^{[1
]}

GOUTTEBEL, MC ^{[1
]}

SAINTAUBERT, B ^{[1
]}

GIRARDOT, PM ^{[1
]}

BRIAND, D ^{[1
]}

JOYEUX, H ^{[1
]}

机构：

[1] CANC INST,NUTR & EXPTL ONCOL LAB,F-34094 MONTPELLIER 5,FRANCE

来源：

CLINICAL NUTRITION | 1992年 / 11卷 / 01期

关键词：

D O I：

10.1016/0261-5614(92)90060-4

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Recent studies have demonstrated that glutamine may be required for mucosal growth and that it is widely utilised by the intestinal tract after surgery. This study has evaluated the effect of massive small bowel resection on plasma and jejunal glutamine and related amino-acids level evolution after surgery. Transection was performed in 6 dogs (control group) and enterectomy in 10 dogs leaving 25 cm of jejunum, associated with colectomy (group 1). Plasma glutamine levels decreased on D2 (p = 0.03) in the resected group while a significant decrease of plasma alanine levels was observed on D2 (p = 0.002), D4, D6 and D8 (p < 0.001). Intestinal mucosa glutamic acid content was increased on D8 in this group (p < 0.001). No changes were observed in the control group. These results suggest that glutamine is a required substrate after massive small bowel resection which could improve the intestinal adaptation encountered after enterectomy.

引用

页码：30 / 34

页数：5

共 21 条

[1]

Windmueller, Glutamine utilization by the small intestine, Advances in Enzymology, 53, pp. 201-237, (1982)

[2]

Wilmore, Smith, O'Dwyer, Et al., The gut: a central organ after surgical stress, Surgery, 104, pp. 917-923, (1988)

[3]

Souba, Scott, Wilmore, Intestinal consumption of intravenously administered fuels, Journal of Parenteral and Enteral Nutrition, 9, pp. 18-22, (1985)

[4]

Souba, Wilmore, Postoperative alteration of arteriovenous exchange of aminoacids across the gastrointestinal tract, Surgery, 94, pp. 342-350, (1983)

[5]

Souba, Smith, Wilmore, Glutamine metabolism by the intestinal tract, Journal of Parenteral and Enteral Nutrition, 9, pp. 608-617, (1985)

[6]

Dowling, Small bowel adaptation and its regulation, Scandinavian Journal of Gastroenterology, 17, pp. 53-74, (1982)

[7]

Williamson, Chir, Intestinal adaptation I Structural functional and cytokinetic changes, New England Journal of Medicine, 25, pp. 1393-1402, (1978)

[8]

Williamson, Chir, Intestinal adaptation II Mechanisms of control, New England Journal of Medicine, 26, pp. 1444-1450, (1978)

[9]

Wilmore, Dudrick, Daly, Et al., The role of the nutrition in the adaptation of the small intestine after massive resection, Surgery Gynecology and Obstetrics, 132, pp. 673-680, (1971)

[10]

Hwang, O'Dwyers, Smith, Wilmore, Preservation of small bowel mucosa using glutamine enriched parenteral nutrition, Surgical Forum, 37, pp. 56-58, (1987)

← 1 2 3 →