TRANSPLACENTAL TRANSFER OF CEFUROXIME IN UNCOMPLICATED PREGNANCIES AND THOSE COMPLICATED BY HYDROPS OR CHANGES IN AMNIOTIC-FLUID VOLUME

被引：8

作者：

HOLT, DE ^{[1
]}

FISK, NM ^{[1
]}

SPENCER, JAD ^{[1
]}

DELOUVOIS, J ^{[1
]}

HURLEY, R ^{[1
]}

HARVEY, D ^{[1
]}

机构：

[1] QUEEN CHARLOTTES & CHELSEA HOSP, ROYAL POSTGRAD MED SCH, INST OBSTET & GYNAECOL, FETAL MED UNIT, LONDON W6 0XG, ENGLAND

来源：

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION | 1993年 / 68卷 / 01期

关键词：

D O I：

10.1136/adc.68.1_Spec_No.54

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The transplacental transfer of cefuroxime was determined at antenatal fetal blood sampling in a cross sectional study of 78 patients between 15-35 weeks' gestation, 8-138 minutes after a maternal intravenous dose of 750 mg. Mean serum cefuroxime concentration, measured by high performance liquid chromatography, was 7-4 (95% confidence interval (CI) 6.8 to 8.1) mg/l in control fetuses; concentrations in hydropic fetuses were similar (6-2 mg/l, CI 4.7 to 7.7) but in fetuses with oligohydramnios they were significantly lower, (4-9 mg/l, CI 3.6 to 6-2). Antibiotic concentration did not correlate with gestational age and remained unchanged by transfusion of packed red cells. We conclude that (i) fetal serum concentrations of cefuroxime obtained after a maternal dose of 750 mg are only adequate for prophylaxis against organisms with a minimum inhibitory concentration of <4 mg/l and (ii) transplacental passage of cefuroxime is significantly reduced in the presence of oligohydramnios.

引用

页码：54 / 57

页数：4

共 25 条

[1]

BARSS VA, 1987, OBSTET GYNECOL, V70, P442

[2] TECHNICAL ASPECTS OF INTRAVASCULAR INTRAUTERINE TRANSFUSIONS - LESSONS LEARNED FROM 33 PROCEDURES [J].