A NOVEL CLASS OF ANTITUMOR METABOLITES FROM THE FUNGUS NATTRASSIA-MANGIFERAE

被引:47
作者
CHU, M
TRUUMEES, I
PATEL, MG
GULLO, VP
BLOOD, C
KING, I
PAI, JK
PUAR, MS
机构
[1] Schering-Plough Research Institute, Kenilworth, NJ 07003
关键词
D O I
10.1016/S0040-4039(00)76213-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Sch 49210, Sch 53514 and Sch 53516 has been isolated from a fungal culture, and identified by analysis of 2D NMR data. Two diacetylation derivatives Sch 53515 and Sch 53517 has been synthesized. These compounds demonstrate inhibitory activity of phospholipase D (PLD), and display potent activity in the antitumor invasion chamber assay.
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页码:1343 / 1346
页数:4
相关论文
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