A NOVEL CLASS OF ANTITUMOR METABOLITES FROM THE FUNGUS NATTRASSIA-MANGIFERAE

被引：47

作者：

CHU, M

TRUUMEES, I

PATEL, MG

GULLO, VP

BLOOD, C

KING, I

PAI, JK

PUAR, MS

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ 07003

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(00)76213-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sch 49210, Sch 53514 and Sch 53516 has been isolated from a fungal culture, and identified by analysis of 2D NMR data. Two diacetylation derivatives Sch 53515 and Sch 53517 has been synthesized. These compounds demonstrate inhibitory activity of phospholipase D (PLD), and display potent activity in the antitumor invasion chamber assay.

引用

页码：1343 / 1346

页数：4