ABSENCE OF AN INHIBITORY EFFECT OF OMEPRAZOLE AND NIZATIDINE ON PHENYTOIN DISPOSITION, A MARKER OF CYP2C ACTIVITY

被引：18

作者：

BACHMANN, KA

SULLIVAN, TJ

JAUREGUI, L

REESE, JH

MILLER, K

LEVINE, L

机构：

[1] ST VINCENTS MED CTR,TOLEDO,OH

[2] LILLY RES LABS,TOLEDO,OH

[3] CTR APPL PHARMACOL,TOLEDO,OH

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1993年 / 36卷 / 04期

关键词：

PHENYTOIN; OMEPRAZOLE; NIZATIDINE; CYP2C;

D O I：

10.1111/j.1365-2125.1993.tb00382.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of omeprazole (40 mg orally per day) and nizatidine (300 mg orally per day) on the disposition of phenytoin (4.5 mg kg-1 p.o. single dose) were studied in 18 healthy, young adult males. Total and unbound plasma concentrations of phenytoin were measured for 48 h after each dose of phenytoin. Neither treatment altered the disposition kinetics of phenytoin, the hydroxylation of which is mediated specifically by cytochromes P450 of the 2C subfamily.

引用

页码：380 / 382

页数：3

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