THE EFFECT OF ACUTE HYPERINSULINEMIA ON PLASMA CHOLESTERYL ESTER TRANSFER PROTEIN-ACTIVITY IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS AND HEALTHY-SUBJECTS

被引:29
作者
SUTHERLAND, WHF
WALKER, RJ
LEWISBARNED, NJ
PRATT, H
TILLMAN, HC
机构
[1] Department of Medicine, University of Otago Medical School, Dunedin
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 1994年 / 43卷 / 11期
关键词
D O I
10.1016/0026-0495(94)90028-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effect of acute hyperinsulinemia on plasma cholesteryl ester (CE) transfer protein (CETP) activity was determined in 11 patients with non-insulin-dependent diabetes mellitus (NIDDM) and 10 healthy subjects. Plasma CETP activity was reduced significantly in NIDDM patients (-37 +/- 59 nmol/mL/h, P < .05) but not in healthy subjects (-7 +/- 37 nmol/mL/h) during insulin infusion. Saline infusion did not alter plasma CETP activity significantly. The change in plasma CETP activity was correlated significantly with the baseline plasma triglyceride (TG) concentration (r = -.523, n = 21, P = .01) and marginally with the concomitant decrease in these levels with acute hyperinsulinemia (r = .413, n = 21, P = .06) in NIDDM patients and healthy subjects combined. These data indicate that acute hyperinsulinemia reduces plasma CETP activity and probably plasma CETP concentration in NIDDM patients, and suggest coordinated regulation of CETP levels and TG metabolism by insulin. Copyright (C) 1994 by W.B. Saunders Company
引用
收藏
页码:1362 / 1366
页数:5
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