STEREOSELECTIVE FORMATION OF BENZ[A]ANTHRACENE (+)-(5S,6R)-OXIDE AND (+)-(8R,9S)-OXIDE BY A HIGHLY PURIFIED AND RECONSTITUTED SYSTEM CONTAINING CYTOCHROME P-450C

被引：49

作者：

VANBLADEREN, PJ

ARMSTRONG, RN

COBB, D

THAKKER, DR

RYAN, DE

THOMAS, PE

SHARMA, ND

BOYD, DR

LEVIN, W

JERINA, DM

机构：

[1] UNIV MARYLAND,DEPT CHEM,COLLEGE PK,MD 20034

[2] QUEENS UNIV BELFAST,DEPT CHEM,BELFAST BT9 5AG,ANTRIM,NORTH IRELAND

[3] HOFFMANN LA ROCHE INC,DEPT BIOCHEM & DRUG METAB,NUTLEY,NJ 07110

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1982年 / 106卷 / 02期

关键词：

D O I：

10.1016/0006-291X(82)91153-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：602 / 609

页数：8

共 26 条

[1] ANTHRACENE 1,2-OXIDE - SYNTHESIS AND ROLE IN THE METABOLISM OF ANTHRACENE BY MAMMALS [J].

AKHTAR, MN ;

HAMILTON, JG ;

BOYD, DR ;

BRAUNSTEIN, A ;

SEIFRIED, HE ;

JERINA, DM .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1979, (06) :1442-1446

[2] STEREOSELECTIVITY OF RAT-LIVER CYTOCHROME P-450C ON FORMATION OF BENZO[A]PYRENE 4,5-OXIDE [J].

ARMSTRON, RN ;

LEVIN, W ;

RYAN, DE ;

THOMAS, PE ;

MAH, HD ;

JERINA, DM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 100 (03) :1077-1084

[3]

ARMSTRONG RN, 1981, J BIOL CHEM, V256, P4726

[4] REACTIONS OF K-REGION OXIDES OF CARCINOGENIC AND RELATED POLYCYCLIC-HYDROCARBONS WITH NUCLEOPHILES - STEREOCHEMISTRY AND REGIOSELECTIVITY [J].

BELAND, FA ;

HARVEY, RG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (16) :4963-4970

[5] SYNTHESIS AND ABSOLUTE STEREOCHEMISTRY OF (+)-BENZ[A]ANTHRACENE AND (-)-BENZ[A]ANTHRACENE 8,9-OXIDE AND DERIVED MAMMALIAN LIVER METABOLITES OF BENZ[A]-ANTHRACENE [J].

BOYD, DR ;

DAWSON, KA ;

GADAGINAMATH, GS ;

HAMILTON, JG ;

MALONE, JF ;

SHARMA, ND .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1981, (01) :94-97

[6] TUMORIGENICITY OF OPTICAL ENANTIOMERS OF DIASTEREOMERIC BENZO[A]PYRENE 7,8-DIOL-9,10-EPOXIDES IN NEWBORN MICE - EXCEPTIONAL ACTIVITY OF(+)-7-BETA, 8-ALPHA-DIHYDROXY-9-ALPHA, 10-ALPHA-EPOXY-7,8.9.10-TETRAHYDROBENZOL[A]PYRENE [J].

BUENING, MK ;

WISLOCKI, PG ;

LEVIN, W ;

YAGI, H ;

THAKKER, DR ;

AKAGI, H ;

KOREEDA, M ;

JERINA, DM ;

CONNEY, AH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (11) :5358-5361

[7] DIFFERENCES IN MUTAGENICITY AND CYTOTOXICITY OF (+)-BENZO[ALPHA]PYRENE AND (-)-BENZO[ALPHA]PYRENE 4,5-OXIDE - SYNERGISTIC INTERACTION OF ENANTIOMERS [J].

CHANG, RL ;

WOOD, AW ;

LEVIN, W ;

MAH, HD ;

THAKKER, DR ;

JERINA, DM ;

CONNEY, AH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (09) :4280-4284

[8] REGIOSPECIFICITY AND STEREOSPECIFICITY IN THE ENZYMATIC CONJUGATION OF GLUTATHIONE WITH +/-BENZO(A)PYRENE 4,5-OXIDE [J].

HERNANDEZ, O ;

WALKER, M ;

COX, RH ;

FOUREMAN, GL ;

SMITH, BR ;

BEND, JR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 96 (04) :1494-1502

[9] C-13 NUCLEAR MAGNETIC-RESONANCE STUDY OF NUCLEOPHILIC ADDITIONS TO BENZO[A]PYRENE 4,5-OXIDE AND OF ITS ACID-CATALYZED REARRANGEMENT [J].

HYLARIDES, MD ;

LYLE, TA ;

DAUB, GH ;

VANDERJAGT, DL .

JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (25) :4652-4657

[10] NOVEL REARRANGEMENTS DURING DEHYDRATION OF NUCLEOPHILE ADDUCTS OF ARENE OXIDES - REAPPRAISAL OF PRE-MERCAPTURIC ACID STRUCTURES [J].

JEFFERY, AM ;

JERINA, DM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (15) :4427-4428

← 1 2 3 →