CLINICAL-APPLICATION OF F-18 FUDR IN GLIOMA PATIENTS - PET STUDY OF NUCLEIC-ACID METABOLISM

被引：12

作者：

KAMEYAMA, M

ISHIWATA, K

TSURUMI, Y

ITOH, J

SATO, K

KATAKURA, R

YOSHIMOTO, T

HATAZAWA, J

ITO, M

IDO, T

机构：

[1] TOHOKU UNIV,SCH MED,DEPT NEUROSURG,SENDAI,MIYAGI,JAPAN

[2] TOHOKU UNIV,CTR CYCLOTRON RI,DIV NUCL MED,SENDAI,MIYAGI,JAPAN

[3] TOHOKU UNIV,CTR CYCLOTRON RI,DIV RADIOPHARMACEUT CHEM,SENDAI,MIYAGI,JAPAN

来源：

JOURNAL OF NEURO-ONCOLOGY | 1995年 / 23卷 / 01期

关键词：

F-18 FLUORO-2'-DEOXYURIDINE; PET; BRAIN TUMOR; GLIOMA; NUCLEIC ACID METABOLISM;

D O I：

10.1007/BF01058459

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Positron emission tomography was used to investigate the metabolism of nucleic acids by F-18-fluoro-2'-deoxyuridine (F-18-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 +/- 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 +/- 0.042 (p < 0.01). This PET-F-18-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.

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页码：53 / 61

页数：9

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