UTILITY OF CYTOKERATIN 20 IN IDENTIFYING THE ORIGIN OF METASTATIC CARCINOMAS IN EFFUSIONS

被引：27

作者：

ASCOLI, V

TACCOGNA, S

SCALZO, CC

NARDI, F

机构：

[1] Laboratorio di Citodiagnostica, Dipartimento di Medicina Sperimentale, Università la Sapienza, Rome

来源：

DIAGNOSTIC CYTOPATHOLOGY | 1995年 / 12卷 / 04期

关键词：

CANCER-RELATED ANTIGENS; IMMUNOCYTOCHEMISTRY; ADENOCARCINOMA; MESOTHELIOMA; MESOTHELIAL CELLS; CYTODIAGNOSIS; COLORECTAL CANCER;

D O I：

10.1002/dc.2840120404

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Using a commercially available monoclonal antibody (K(s)20.1) and the avidin-biotin peroxidase method on cytospins and cell blocks, we analyzed cytokeratin (CK) 20 expression in 169 serous effusions. Cytoplasmic staining was observed in 44/151 malignant fluids. Colon, gastric, and pancreatic adenocarcinomas and mucinous ovarian tumors were most frequently positive. Single cases of transitional-cell and squamous cell carcinomas were reactive as well. Lung and breast cancers were mostly negative. Nonmucinous ovarian tumors were invariably unlabeled as were mesotheliomas and normal mesothelial cells. The study shows that CK 20 is valuable in distinguishing tumor cell origin in effusions. In particular, it identifies a set of carcinomas with the majority arising from the gastrointestinal tract, and represents a highly characteristics marker for colorectal cancer. Diagn Cytopathol 1995; 12:303-308. (C) 1995 Wiley-Liss, Inc.

引用

页码：303 / 308

页数：6

共 22 条

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