SUBSTRATE INDUCED SPIN STATE CHANGES IN CYTOCHROME P450

被引：34

作者：

WHYSNER, JA

RAMSEYER, J

KAZMI, GM

HARDING, BW

机构：

[1] Department of Biochemistry University, Southern California School of Medicine Los Angeles

[2] Department of Medicine University, Southern California School of Medicine Los Angeles

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 36卷 / 05期

关键词：

D O I：

10.1016/0006-291X(69)90679-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deoxycorticosterone (DOC) produces 385 and 645 nm peaks and 420, 530 and 575 nm troughs, and 20αOH-cholesterol produces 420, 530 and 575 nm peaks and 385 and 645 nm troughs in the difference spectra of adrenal cortical submitochondrial particles. Electron spin resonance studies show that 20αOH-cholesterol produces an increase and 11-deoxycortisol or DOC produce a decrease in the low-spin signal of P450. These results suggest to us that the substrate induced difference spectra may be the result of a spin state shift in cytochrome P450. © 1969.

引用

页码：795 / &

共 8 条

[1] ABSORPTION SPECTRA, MAGNETIC MOMENTS AND BINDING OF IRON IN SOME HAEMOPROTEINS [J].