INCREASED CATECHOLAMINE EXCRETION AFTER LABETALOL THERAPY - SPURIOUS EFFECT OF DRUG METABOLITES

被引：23

作者：

MIANO, L

KOLLOCH, R

DEQUATTRO, V

机构：

[1] UNIV SO CALIF,LOS ANGELES CTY MED CTR,DEPT MED,LOS ANGELES,CA 90033

[2] WHITE MEM MED CTR,DEPT MED,LOS ANGELES,CA 90033

来源：

CLINICA CHIMICA ACTA | 1979年 / 95卷 / 02期

关键词：

D O I：

10.1016/0009-8981(79)90361-9

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Patients with essential hypertension were treated for four weeks with the alpha- and beta-adreno-receptor blocking agent labetalol. Urinary excretion of total catecholamines, metanephrine plus normetanephrine and vanillylmandelic acid was measured with various methods before and during treatment. An unidentified substance interfering with the fluorimetric method for catecholamines and the photometric assay for metanephrines caused falsely high values of those substances. Using appropriate methodology no changes of total catecholamines, metanephrine plus normetanephrine and vanillylmandelic acid excretion were found after labetalol therapy. Our findings are important in preventing errors in the diagnosis of pheochromocytoma as well as in the evaluation of the effects of labetalol on the sympathetic nervous system in man. © 1979.

引用

页码：211 / 217

页数：7

共 10 条

[1] A SIMPLIFIED METHOD FOR DIFFERENTIAL ESTIMATION OF METANEPHRINE AND NORMETANEPHRINE IN URINE [J].