INTRATHECAL SOMATOSTATIN PRODUCES EFFECTS DEPENDENT ON THE INTERVAL BETWEEN CATHETER IMPLANTATION AND DRUG INJECTION

被引:9
作者
DIRKSEN, R [1 ]
LEROU, J [1 ]
NIJHUIS, GMM [1 ]
BOOIJ, LHDJ [1 ]
JURNA, I [1 ]
机构
[1] UNIV SAARLAND, INST PHARMAKOL, W-6650 HOMBURG, GERMANY
关键词
D O I
10.1016/0024-3205(90)90199-2
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Intrathecal (i.t.) injection of somatostatin has been reported to depress nociceptive reflexes as well as to cause severe disturbance of somatomotor performance. The present study was designed to assess the dependence of these effects on the dose and the interval between implantation of the catheter and i.t. injection of somatostatin in rats. The effects produced by i.t. injection of somatostatin consisted of an increase in the response latencies of nociceptive responses to noxious heat, impairment of motor performance and grooming behavior, convulsions, and death. Except for grooming behavior, these were related in incidence and degree to the dose and the interval, the potency of somatostatin being highest at short intervals. Sham operations also affected the effectiveness of somatostatin. © 1990.
引用
收藏
页码:1347 / 1354
页数:8
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