ANALYSIS OF THE ANEUPLOIDY INDUCING CAPACITY OF 2-CHLOROBENZYLIDENE MALONITRILE (CS) AND METABOLITES IN V79 CHINESE-HAMSTER CELLS

被引：5

作者：

SCHMID, E

BAUCHINGER, M

机构：

[1] Institut für Strahlenbiologie, GSF-Forschungszentrum für Umwelt und Gesundheit

来源：

MUTAGENESIS | 1991年 / 6卷 / 04期

关键词：

D O I：

10.1093/mutage/6.4.303

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The aneuploidy inducing capacity of 2-chlorobenzylidene malonitrile (CS), a chemical used as a riot control agent, and its hydrolysis products omicron-chlorobenzaldehyde and malonitrile was studied at various exposure conditions in V79 Chinese hamster cells. Chromosomes were counted in metaphase preparations with preserved cytoplasm. A significant increase in the number of aneuploid cells was found after CS and omicron-chlorobenzaldehyde exposure but not after malonitrile exposure. Omicron-chlorobenzaldehyde, which also induced high levels of polyploid cells, seems to be an important metabolite for the aneuploidogenic effectiveness of CS.

引用

页码：303 / 305

页数：3

共 7 条

[1]

CUCINELL SA, 1971, FED PROC, V30, P86

[2] THE EFFECT OF MICHLER KETONE ON CELL-DIVISION, CHROMOSOME-NUMBER AND STRUCTURE IN CULTURED CHINESE-HAMSTER CELLS [J].