TAXOL - A NEW AND EFFECTIVE ANTICANCER DRUG

被引:143
作者
SLICHENMYER, WJ [1 ]
VONHOFF, DD [1 ]
机构
[1] UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV ONCOL,SAN ANTONIO,TX 78284
关键词
BREAST CANCER; CANCER CHEMOTHERAPY; MICROTUBULES; NATURAL PRODUCTS; OVARIAN CANCER; TAXOL;
D O I
10.1097/00001813-199112000-00002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Taxol is a new anti-cancer drug that is a natural product derived from the bark of the Pacific Yew tree. The drug promotes polymerization and stabilization of tubulin to microtubules and interferes with the mitotic spindle. Clinical trials indicate that taxol is effective in the treatment of patients with refractory ovarian cancer, breast cancer, malignant melanoma and probably other solid tumors. Toxicities include anaphylactoid reactions, leukopenia, peripheral neuropathy and oropharyngeal mucositis. increased supplies of the drug are required to support further phase II and III testing.
引用
收藏
页码:519 / 530
页数:12
相关论文
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