DEGRADATION OF POLYBUTYL 2-CYANOACRYLATE MICROPARTICLES

被引：20

作者：

STEIN, M ^{[1
]}

HAMACHER, E ^{[1
]}

机构：

[1] INST DIAGNOST RES,BERLIN,GERMANY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 80卷 / 2-3期

关键词：

CYANOACRYLATE; MICROPARTICLE; DEGRADATION; HYDROLYSIS;

D O I：

10.1016/0378-5173(92)90292-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polybutyl 2-cyanoacrylate microparticles were incubated in buffer solution at pH 3.0, 6.0 and 10.0 at room temperature and at 50-degrees-C, and in dog serum at 37-degrees-C. Complete degradation took place at pH 10.0 within 9 days (room temperature) or 24 h (50-degrees-C) and at pH 6.0 within 35 days (50-degrees-C). At pH 3.0 and 6.0 (room temperature) only slight degradation was observed. Almost complete hydrolysis occurred in dog serum within 3.5 h.

引用

页码：R11 / R13

页数：3

共 8 条

[1]

COUVREUR P, 1988, CRIT REV THER DRUG, V5, P1

[2] POLYCYANOACRYLATE NANOCAPSULES AS POTENTIAL LYSOSOMOTROPIC CARRIERS - PREPARATION, MORPHOLOGICAL AND SORPTIVE PROPERTIES [J].