FETAL LYMPHOCYTE-T SUBPOPULATIONS IN NORMAL PREGNANCIES

被引：38

作者：

THILAGANATHAN, B ^{[1
]}

MANSUR, CA ^{[1
]}

MORGAN, G ^{[1
]}

NICOLAIDES, KH ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL HOSP,SCH MED,HARRIS BIRTHRIGHT RES CTR FETAL MED,LONDON SE5 8RX,ENGLAND

来源：

FETAL DIAGNOSIS AND THERAPY | 1992年 / 7卷 / 02期

关键词：

CORDOCENTESIS; FETAL BLOOD; FLOW CYTOMETRY; LYMPHOCYTES-T; FETAL IMMUNOLOGY;

D O I：

10.1159/000263651

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Peripheral blood T lymphocyte subpopulations were measured, using a fluorescence-activated cell sorter, in fetal blood samples obtained either by cordocentesis (n = 118) or at elective caesarean section (n = 14). Both the numbers and percentages of the total T lymphocytes (CD3+) and T-helper lymphocytes (CD4+) increased exponentially with gestation from respective means of 46% (1.15 X 10(9)/l) and 29% (0.70 X 10(9)/l) at 16 weeks to a plateau of 75% (3.11 X 10(9)/l) and 54% (2.10 X 10(9)/l) at 34 weeks. Similarly, the number of suppressor/cytotoxic T lymphocytes (CD8+) increased linearly with gestation from a mean of 22% (0.55 X 10(9)/1) at 16 weeks to 24% (0.96 X 10(9)/l) at 40 weeks; there were no natural cytotoxic T lymphocytes (CD3+CD56+) in any of the fetal blood samples. The helper-to-suppressor T lymphocyte ratio (CD4/CD8) increased exponentially with gestation from a mean of 1.22 at 16 weeks to 2.57 at 28 weeks. The alterations in T lymphocyte subpopulations were accompanied by changes in the expression of CD45RA, L-selectin, CD25 and HLA-DR. These alterations in T lymphocyte subpopulations with gestation reflect the pattern of maturation and development of the fetal cell-mediated immune system.

引用

页码：53 / 61

页数：9