TOTAL SYNTHESIS OF HALICHONDRINS - ENANTIOSELECTIVE CONSTRUCTION OF A HOMOCHIRAL TETRACYCLIC KLMN-RING INTERMEDIATE FROM D-MANNITOL

被引：25

作者：

DIFRANCO, E ^{[1
]}

RAVIKUMAR, VT ^{[1
]}

SALOMON, RG ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)73673-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient strategy exploiting C2 symmetry and featuring diastereoselective conjugate addition of Li2Me2CuCN to a gamma-alkoxy-alpha,beta-unsaturated acylsilane and diastereoselective spiroketalization provides a key tetracyclic KLMN-ring intermediate for halichondrin B from D-mannitol.

引用

页码：3247 / 3250

页数：4

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