CURRENT PROGRESS IN THE DEVELOPMENT OF THE B-SUBUNITS OF CHOLERA-TOXIN AND ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN AS CARRIERS FOR THE ORAL DELIVERY OF HETEROLOGOUS ANTIGENS AND EPITOPES

被引：57

作者：

NASHAR, TO ^{[1
]}

AMIN, T ^{[1
]}

MARCELLO, A ^{[1
]}

HIRST, TR ^{[1
]}

机构：

[1] UNIV KENT, BIOL LAB, CANTERBURY CT2 7NJ, KENT, ENGLAND

来源：

VACCINE | 1993年 / 11卷 / 02期

基金：

英国惠康基金;

关键词：

VACCINE DESIGN; GENE FUSIONS; MUCOSAL IMMUNITY; ORAL ADJUVANTS;

D O I：

10.1016/0264-410X(93)90023-Q

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of non-living carrier systems for delivery of protective antigens or epitopes to the immune system represents both a fundamental and an applied aspect of vaccinology. A wide range of carrier systems, ranging from inert supports to proteins that exert direct immunomodulating effects on the immune response, are being studied. In this overview we describe the current progress in the development of the B-subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as potential protein carriers for the oral delivery of chemically and genetically attached antigens and epitopes.

引用

页码：235 / 240

页数：6

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