CATALYTICALLY ACTIVE SPECIES FOR CECL3-INDUCED DNA HYDROLYSIS

被引：44

作者：

KOMIYAMA, M ^{[1
]}

KODAMA, T ^{[1
]}

TAKEDA, N ^{[1
]}

SUMAOKA, J ^{[1
]}

SHIIBA, T ^{[1
]}

MATSUMOTO, Y ^{[1
]}

YASHIRO, M ^{[1
]}

机构：

[1] UNIV TSUKUBA,INST MAT SCI,TSUKUBA,IBARAKI 305,JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1994年 / 115卷 / 05期

关键词：

ARTIFICIAL RESTRICTION ENZYME; CERIUM(III) CHLORIDE; CE(IV) ION; DNA HYDROLYSIS;

D O I：

10.1093/oxfordjournals.jbchem.a124419

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cerium(III) chloride efficiently hydrolyzes DNA at pH 7 under aerobic conditions. A titration study showed that Ce(III) is oxidized to Ce(IV) in the reaction mixture and the resultant Ce(IV) is responsible for the DNA hydrolysis.

引用

页码：809 / 810

页数：2

共 13 条

[1] METALS AND DNA - MOLECULAR LEFT-HANDED COMPLEMENTS [J].

BARTON, JK .

SCIENCE, 1986, 233 (4765) :727-734

[2]

Burgess J, 1978, METAL IONS SOLUTION, P267

[3] CO(III) COMPLEX PROMOTED HYDROLYSIS OF PHOSPHATE DIESTERS - COMPARISON IN REACTIVITY OF RIGID CIS-DIAQUOTETRAAZACOBALT(III) COMPLEXES [J].

CHIN, J ;

BANASZCZYK, M ;

JUBIAN, V ;

ZOU, X .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (01) :186-190

[4] NONENZYMATIC SEQUENCE-SPECIFIC CLEAVAGE OF SINGLE-STRANDED-DNA [J].

CHU, BCF ;

ORGEL, LE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (04) :963-967

[5]

COTTON FA, 1980, ADV INORG CHEM, pCH23

[6] DESIGN OF SEQUENCE-SPECIFIC DNA-BINDING MOLECULES [J].

DERVAN, PB .

SCIENCE, 1986, 232 (4749) :464-471

[7] A LANTHANUM MACROCYCLE CATALYZED-HYDROLYSIS OF A PHOSPHATE TRIESTER [J].

HAY, RW ;

GOVAN, N .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (09) :714-715

[8] UNPRECEDENTEDLY FAST HYDROLYSIS OF THE RNA DINUCLEOSIDE MONOPHOSPHATES APA AND UPU BY RARE-EARTH-METAL IONS [J].

KOMIYAMA, M ;

MATSUMURA, K ;

MATSUMOTO, Y .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (08) :640-641

[9] HYDROLYSIS OF OLIGODNAS BY LANTHANIDE METAL(III) CHLORIDE [J].

KOMIYAMA, M ;

MATSUMOTO, Y ;

HAYASHI, N ;

MATSUMURA, K ;

TAKEDA, N ;

WATANABE, K .

POLYMER JOURNAL, 1993, 25 (11) :1211-1214

[10]

Matsumoto Y, 1992, Nucleic Acids Symp Ser, P33

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