OPOSSUM AS AN ANIMAL-MODEL FOR STUDYING RADIATION ESOPHAGITIS

被引：17

作者：

NORTHWAY, MG

LIBSHITZ, HI

WEST, JJ

WITHERS, HR

MUKHOPADHYAY, AK

OSBORNE, BM

SZWARC, IA

DODD, GD

机构：

[1] UNIV TEXAS, MD ANDERSON HOSP & TUMOR INST, TEXAS MED CTR, CTR CANC, DEPT DIAGNOST RADIOL, HOUSTON, TX 77030 USA

[2] UNIV TEXAS, MD ANDERSON HOSP & TUMOR INST,TEXAS MED CTR, CTR CANC,DEPT EXPTL RADIOTHERAPY, HOUSTON, TX 77030 USA

[3] UNIV TEXAS, MD ANDERSON HOSP & TUMOR INST,TEXAS MED CTR, CTR CANC,DEPT PATHOL, HOUSTON, TX 77030 USA

来源：

RADIOLOGY | 1979年 / 131卷 / 03期

关键词：

D O I：

10.1148/131.3.731

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Six opossums were evaluated as a possible animal model of radiation esophagitis. In a single exposure to the esophagus, 4 animals received 60Co radiation of various doses; 2 served as controls. Pre- and postirradiation evaluations using fiberoptic endoscopy, mucosal biopsy, barium esophagography and manometry were performed. Esophagitis developed at 1 wk in irradiated animals. Opossums receiving 17.5, 20 and 22.5 Gy [gray] (1750; 2000; and 2250 rad) became anorexic 1 wk postirradiation, and abnormal motility subsequently developed. The controls and the animal receiving 15 Gy (1500 rad) remained normal. Histological changes in the irradiated opossum esophagus resembled those in humans.

引用

页码：731 / 735

页数：5

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