AMYLOID-BETA PROTEIN SUBSTITUENT PEPTIDES DO NOT INTERACT WITH THE SUBSTANCE-P RECEPTOR EXPRESSED IN CULTURED-CELLS

被引：30

作者：

MITSUHASHI, M

AKITAYA, T

TURK, CW

PAYAN, DG

机构：

[1] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

来源：

MOLECULAR BRAIN RESEARCH | 1991年 / 11卷 / 02期

关键词：

AMYLOID-BETA PROTEIN; SUBSTANCE-P; SUBSTANCE-P RECEPTOR; ALZHEIMERS DISEASE; CYTOSOLIC CA-2+; FURA-2;

D O I：

10.1016/0169-328X(91)90120-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The amyloid beta-protein (ABP) has been shown to interact with the substance P (SP) receptor in a cell culture model that may mimic the pathogenesis of Alzheimer's disease. In the present study, however, 4 fragments of ABP (beta-1-42, beta-1-16, beta-17-28, and beta-25-35) failed to interact with SP-induced Ca2+ mobilization in SP receptor-expressing cultured cells. Therefore, the action of these ABP-related peptides in our cultured cells is unrelated to the SP receptor.

引用

页码：177 / 180

页数：4

共 20 条

[1] ENHANCEMENT OF PHAGOCYTOSIS - A NEWLY FOUND ACTIVITY OF SUBSTANCE-P RESIDING IN ITS N-TERMINAL TETRAPEPTIDE SEQUENCE [J].