OXYTOCIN EXCITES NEURONS IN THE BED NUCLEUS OF THE STRIA TERMINALIS OF THE LACTATING RAT INVITRO

被引：44

作者：

INGRAM, CD

CUTLER, KL

WAKERLEY, JB

机构：

[1] Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol

来源：

BRAIN RESEARCH | 1990年 / 527卷 / 01期

基金：

英国医学研究理事会;

关键词：

Bed nucleus of the stria terminalis; Brain slice; Electrophysiology; Lactation; Oxytocin; Vasopressin;

D O I：

10.1016/0006-8993(90)91078-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Unit recordings were made in the bed nucleus of the stria terminalis in brain slices obtained from lactating rats. Addition of 10-8 to 10-6 M oxytocin to the perifusate caused a reversible and repeatable excitation in 28/53 (53%) of neurones. The excitatory effect of oxytocin was completely blocked in the presence of the antagonist [d(CH2)5d-Tyr(OEt)2, Val4, Cit8]vasopressin (5 × 10-7 M) and a smaller excitation was achieved with equimolar concentration of arginine vasopressin, implicating the involvement of an oxytocin receptor. This effect is discussed in relation to the actions of centrally administered oxytocin in the lactating rat. © 1990.

引用

页码：167 / 170

页数：4

共 29 条

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