PHYLOGENETIC AND PHYSICAL ANALYSIS OF THE 5' LEADER RNA SEQUENCES OF AVIAN RETROVIRUSES

被引：34

作者：

HACKETT, PB

DALTON, MW

JOHNSON, DP

PETERSEN, RB

机构：

[1] UNIV MINNESOTA,INST HUMAN GENET,ST PAUL,MN 55108

[2] UNIV MINNESOTA,CTR MOLEC BIOL COMP,ST PAUL,MN 55108

来源：

NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 24期

关键词：

D O I：

10.1093/nar/19.24.6929

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A study of the secondary structures of the 5'-leader RNA sequences of avian leukosis/sarcoma viruses was conducted using phylogenetic sequence alignment, theoretical structures calculated from base-pairing interactions involving the calculated minimal DELTA-G values, and RNaseT1 sensitivitiy. The results suggest that all of the avian retroviral RNA leaders may be able to adopt similar conformations. Open reading frames in the leader RNAs may be positioned to facilitate viral activities such as translation and packaging of the genomic RNA into virus particles.

引用

页码：6929 / 6934

页数：6

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