DP POLYMORPHISM IN HLA-A1,HLA-B8,HLA-DR3 EXTENDED HAPLOTYPES ASSOCIATED WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS AND SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：19

作者：

BISHOF, NA ^{[1
]}

WELCH, TR ^{[1
]}

BEISCHEL, LS ^{[1
]}

CARSON, D ^{[1
]}

DONNELLY, PA ^{[1
]}

机构：

[1] CHILDRENS HOSP RES FDN,DIV NEPHROL,ELLAND & BETHESDA AVE,CINCINNATI,OH 45229

来源：

PEDIATRIC NEPHROLOGY | 1993年 / 7卷 / 03期

关键词：

MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; AUTOIMMUNITY; MAJOR HISTOCOMPATIBILITY COMPLEX; HLA-DP;

D O I：

10.1007/BF00853205

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We and others have shown an association between autoimmune disorders and the major histocompatibility complex extended haplotype HLA-A1,-B8,-SCO1, -DR3. The primary gene or genes within this haplotype conferring such susceptibility, however, have not been defined. In this study, we tested the hypothesis that linkage disequilibrium in this haplotype extends through the DP locus, and that DP type may be linked to membranoproliferative glomerulonephritis (MPGN) and systemic lupus erythematosus (SLE). DP and DQ typing was performed by restriction fragment length polymorphism analysis for 43 chromosomes (19 healthy controls, 9 SLE, 15 MPGN) bearing the -A1,-B8,-SCO1,-DR3 extended haplotype. Although all were DQw2, a variety of DP types were identified (DPw1, 0.26; DPw2, 0.09; DPw3, 0.14; DPw4, 0.44). Although DPw1 was represented on extended haplotypes with greater frequency than on 113 non-A1,-B8,-SCO1,-DR3 haplotypes (0.26 vs. 0.03; P <0.001), there were no significant differences between healthy individuals with this haplotype and those with autoimmune disease. We conclude that the strong linkage disequilibrium of this haplotype breaks down between the DQ and DP loci. Loci important to disease susceptibility, therefore, are more likely to occur telomeric to DP.

引用

页码：243 / 246

页数：4

共 24 条

[1]

Welch T.R., Beischel L., Balakrishnan K., Quinlan M., West C.D., Major-histocompatibility-complex extended haplotypes in membranoproliferative glomerulonephritis, N Engl J Med, 314, (1986)

[2]

Raum D., Awdeh Z., Yunis E.J., Alper C.A., Gabbay K.H., Extended major histocompatibility complex haplotypes in type I diabetes mellitus, J Clin Invest, 74, (1984)

[3]

Alper C.A., Fleischnick E., Awdeh Z., Katz A.J., Yunis E.J., Extended major histocompatibility complex haplotypes in patients with gluten-sensitive enteropathy, J Clin Invest, 79, (1987)

[4]

Welch T.R., Beischel L.S., Balakrishnan K., Quinlan M., West C.D., Major histocompatibility complex extended haplotypes in systemic lupus erythematosus, Dis Markers, 6, (1988)

[5]

Matsui Y., Alosco S.M., Awdeh Z., Duquesnoy R.J., Page P.L., Hartzman R.J., Alper C.A., Yunis E.J., Linkage disequilibrium of HLA-SB1 with the HLA-A1,B8,DR3,SCO1 and of HLA-SB4 with the HLA-A26,Bw38,Dw10,DR4,SC21 extended haplotypes, Immunogenetics, 20, (1984)

[6]

Bolsover W.J., Hall M.A., Vaughan R.W., Welsh K.I., Ciclitira P.J., A family study confirms that the HLA-DP associations with celiac disease are the result of an extended HLA-DR3 haplotype, Hum Immunol, 31, (1991)

[7]

West C.D., McAda A.J., Membranoproliferative glomerulonephritis, Textbook of Nephrology, vol 1, pp. 46-52, (1983)

[8]

Tan E.M., Cohen A.S., Fries J.F., Masi A.T., McShane D.J., Rothfield N.F., Schaller J.G., Talal N., Winchester R.J., The 1982 revised criteria for the classification of systemic lupus erythematosus, Arthritis Rheum, 25, (1982)

[9]

Bell G.I., Karam J.H., Rutter W.J., Polymorphic DNA region adjacent to the 5′ end of the human insulin gene, Proc Natl Acad Sci USA, 78, (1981)

[10]

Paulsen G., Markussen G., Demopulos J., Tiercy J.M., van Tonder S., Quillivic F., RFLP standardization report for DQ Beta/HindIII, Immunobiology of HLA, (1989)

← 1 2 3 →