MASTOCYTOSIS AND COEXISTENT NON-HODGKINS-LYMPHOMA AND MYELOPROLIFERATIVE DISORDERS

被引：15

作者：

HUTCHINSON, RM

机构：

[1] Department of Haematology, Leicester Royal Infirmary, Leicester

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 7卷 / 1-2期

关键词：

MASTOCYTOSIS; NON-HODGKINS LYMPHOMA; MYELOPROLIFERATIVE DISORDERS; MAST CELLS; COEXISTENCE;

D O I：

10.3109/10428199209053599

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Generalised mastocytosis is a rare condition characterised by the clinical features of the release of vasoactive peptides from tissue mast cells infiltrating in the reticuloendothelial tissues. The mast cell however appears to have its origin in the pluripotential bone marrow stem cell committed to a basophil and it is therefore not surprising that myeloproliferative and myelodysplastic disorders commonly co-exist or terminate the clinical phase of mastocytosis. Both abnormal proliferation and maturation of the myeloid committed cells are found. Non-Hodgkin's lymphoma can occur before and after mastocytosis becomes manifest. While this is statistically a random event the relationship between lymphokines and mast cell differentiation and proliferation raises the possibility of a benign reactive lymphoid event eventually becoming malignant. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：29 / 36

页数：8

共 28 条

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