HIGH-DENSITY GENETIC-MAP OF THE BRCA1 REGION OF CHROMOSOME-17Q12-Q21

被引：104

作者：

ANDERSON, LA

FRIEDMAN, L

OSBORNELAWRENCE, S

LYNCH, E

WEISSENBACH, J

BOWCOCK, A

KING, MC

机构：

[1] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,BERKELEY,CA 94720

[2] UNIV CALIF BERKELEY,SCH PUBL HLTH,BERKELEY,CA 94720

[3] UNIV TEXAS,SW MED CTR,DEPT PEDIAT,DALLAS,TX 75235

[4] GENETHON,F-91000 EVRY,FRANCE

来源：

GENOMICS | 1993年 / 17卷 / 03期

关键词：

D O I：

10.1006/geno.1993.1381

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To facilitate the positional cloning of the breast-ovarian cancer gene BRCA1, we constructed a high-density genetic map of the 8.3-cM interval between D17S250 and GIP on chromosome 17q12-q21. Markers were mapped by linkage in tbe CEPH and in extended kindreds in our breast cancer series. The map comprises 33 ordered polymorphisms, including 12 genes and 21 anonymous markers, yielding an average of one polymorphism every 250 kb. Twenty-five of the markers are PCR-based systems. The order of polymorphic genes and markers is cen-D17S250-D17S518-HER2-THRA1-RARA-D17S80-KRT10-[D17S800-[D17S857]-GAS- D17S856-EDH17B-D17S855-D17S859-D17S858-[PPY-D17S78]-D17S183-EPB3-D17S579 -D17S509-[D17S508-D17S190 = D17S810]-D17S791-[D17S181 = D17S806]-D17S797-HOX2B-GP3A-[D17S507 = GIP]-qter. BRCA1 lies in the middle of the interval, between THRA1 and D17S183. Markers from this map can be used to determine whether cancer is linked to BRCA1 in families, to evaluate whether tumors have lost heterozygoslty at loci in the region, and to identify probes for characterizing chromosomal rearrangements from patients and from tumors. © 1993 Academic Press, Inc.

引用

页码：618 / 623

页数：6

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