SOME PRELIMINARY DATA ON THE NATURE STRUCTURE OF THE PC-GLYCAN OF THE MAJOR EXCRETORY-SECRETORY PRODUCT OF ACANTHOCHEILONEMA-VITEAE (ES-62)

被引：17

作者：

HARNETT, W

FRAME, MJ

NOR, ZM

MACDONALD, M

HOUSTON, KM

机构：

[1] Department of Immunology, University of Strathclyde, Glasgow

来源：

PARASITE | 1994年 / 1卷 / 02期

关键词：

EXCRETORY-SECRETARY PRODUCT; PHOSPHORYLCHOLINE; GLYCAN ANALYSIS; FILARIASIS;

D O I：

10.1051/parasite/1994012179

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The structure of the PC-glycan of the major excretory-secretory product (ES-62) of Acanthocheilonema viteae has been investigated using endoglycosidases and lectins. Results obtained raise the possibility that it may be of the high mannose type. This, and the insensitivity of the PC-glycan to treatments which remove PC or choline from bacterial PC-glycans, suggests that it may be more analogous to fungal, than to bacterial PC-containing glycans.

引用

页码：179 / 181

页数：3

共 16 条

[1]

Baldo B.A., Fletcher T.C., Pfpys J., Isolation of a pep-tido-polysaccharide from the dermatophyte Epidermophyton floccosum and a study of its reaction with human C-reactive protein and a mouse anti-phosphorylcholine myeloma serum, Immunology, 32, pp. 831-842, (1977)

[2]

Beckmann E., Levitt D., Phosphorylcholine on Streptococcus pneumoniae R36a is responsible for in vitro polyclonal antibody secretion by human peripheral blood lymphocytes, Journal of Immunology, 132, pp. 2174-2176, (1984)

[3]

Bkkuky J.G., LABORATORY TECHNIQUES IN BIOCHEMISTRY' AND MOLECULAR BIOLOGY, GLYCOPROTEIN AND PROTEOGLYCAN TECHNIQUES, 16, (1983)

[4]

Bennet L.G., Bishop C.T., Structure of the type XXVII Streptococcus pneumoniae (Pneumococcal) capsular polysaccharide, Canadian Journal of Chemistry, 55, pp. 8-16, (1977)

[5]

Gabel C.A., Goldberg D.E., Korneield S., Lysosomal enzyme oligosaccharide phosphorylation in mouse lymphoma cells: Specificity and kinetics of binding to the mannose 6-phosphate receptor, In Vivo. Journal of Cell Biology, 95, pp. 536-543, (1982)

[6]

Harnett W., Houston K.M., Amess R., Worms M.J., Acanthocheilonema viteae: Phosphorylcholine is attached to the major excretory-secretory product via an N-linked glycan, Experimental Parasitology, 77, pp. 498-502

[7]

Hamnett W., Harnett M.M., Inhibition of murine B cell proliferation and downregulation of protein kinase C levels by a phosphorylcholine-containing filarial excretory-secretory product, Journal of Immunology, 151, pp. 4829-4837, (1993)

[8]

Harneti V., Parkhoise R.M.E., The nature and function of nematode surface and excretory-secretory antigens, Perspectives in Nematode Physiology and Biochemistry, (1994)

[9]

Harnett W., Worms M.J., Kapil A., Grainger M., Parkhoise R.M.E., Origin, kinetics of circulation and fate in vivo of the major excretory-secretory product of Acanthocheilonema viteae, Parasitology, 99, pp. 229-239, (1989)

[10]

Krug L., Truesdale N.J., Kent C., A simplified assay for phospholipase C, Analytical Biochemistry, 97, pp. 43-47, (1979)

← 1 2 →