MOLECULAR-BASIS FOR THE DEVELOPMENT OF INDIVIDUAL-DIFFERENCES IN THE HYPOTHALAMIC-PITUITARY-ADRENAL STRESS-RESPONSE

被引：105

作者：

MEANEY, MJ ^{[1
]}

BHATNAGAR, S ^{[1
]}

DIORIO, J ^{[1
]}

LAROCQUE, S ^{[1
]}

FRANCIS, D ^{[1
]}

ODONNELL, D ^{[1
]}

SHANKS, N ^{[1
]}

SHARMA, S ^{[1
]}

SMYTHE, J ^{[1
]}

VIAU, V ^{[1
]}

机构：

[1] MCGILL UNIV, DOUGLAS HOSP,RES CTR,DEPT NEUROL & NEUROSURG, DEV NEUROENDOCRINOL LAB, MONTREAL H4H 1R3, PQ, CANADA

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 1993年 / 13卷 / 04期

关键词：

HYPOTHALAMIC-PITUITARY-ADRENAL RESPONSE; STRESS; RATS; HANDLING;

D O I：

10.1007/BF00711576

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. Several years ago, investigators described the effects of infantile handling on the development of hypothalamic-pituitary-adrenal (HPA) responses to stress in the rat. Rat pups exposed to brief periods of innocuous handling early in life showed reduced HPA responses to a wide variety of stressors, and the effect persists throughout the life of the animal. These effects are robust and provide an excellent model for understanding how early environmental stimuli, which are external to the organism, alter neural differentiation and, thus, neuroendocrine responsivity to stress. 2. This paper reviews the endocrine mechanisms affected by early handling and our current understanding of the neural transduction of environmental events and their effects at the level of the target neurons (in the hippocampus and frontal cortex). 3. In brief, handling serves EO increase glucocorticoid receptor gene transcription, increasing sensitivity to glucocorticoid negative feedback regulation and, thus, altering the activity within hypothalamic corticotropin-releasing factor/vasopressin neurons. Together these changes serve to determine neuroendocrine responsivity to stress.

引用

页码：321 / 347

页数：27

共 106 条

[1] EFFECTS OF EARLY EXPERIENCE ON ADRENOCORTICAL REACTIVITY [J].