ANTAGONISM BY ANTIMUSCARINIC AND GANGLION-BLOCKING DRUGS OF SOME OF BEHAVIOURAL EFFECTS OF NICOTINE

被引：47

作者：

MORRISON, CF

GOODYEAR, JM

SELLERS, CM

机构：

[1] Tobacco Research Council Laboratories, Harrogate

来源：

PSYCHOPHARMACOLOGIA | 1969年 / 15卷 / 05期

关键词：

Antimuscarinic Drugs; Ganglion-Blocking Drugs; Nicotine; Operant Conditioning; Psychopharmacology;

D O I：

10.1007/BF00403709

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

The effects of nicotine on bar-pressing behaviour in the rat are blocked by mecamylamine. The depressant phase of the effect is blocked by atropine, supporting the conclusion that this depression is mediated by released acetylcholine. The quaternary compounds chlorisondamine and atropine methylnitrate also antagonise the behavioural effects of nicotine but the doses required for this are far in excess of those which are effective peripherally, suggesting that the sites of interaction are central. © 1969 Springer-Verlag.

引用

页码：341 / &

共 7 条

[1] SOME PHYSICO-CHEMICAL FACTORS IN DRUG ACTION [J].