CIRCULATING ANTIBODIES TO CONNECTIVE-TISSUE MICROFIBRILS AND DERMAL IMMUNOGLOBULIN DEPOSITS IN LEPROSY

被引：19

作者：

LINDER, E

LEHTO, VP

STENMAN, S

LINDQVIST, K

BJORVATN, B

BERGQUIST, R

机构：

[1] UNIV HELSINKI,DEPT PATHOL,SF-00290 HELSINKI 29,FINLAND

[2] ARMAUER HANSEN RES INST,ADDIS ABABA,ETHIOPIA

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1979年 / 13卷 / 01期

关键词：

D O I：

10.1016/0090-1229(79)90014-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Subepidermal fibrillar deposits containing IgM immunoglobulin occur in apparently normal skin from leprosy patients. The distribution of the deposits is similar to that of the microfibrillar epidermis anchoring system which consists of elastic fibers. The deposits may be related to the presence of a novel autoantibody reacting with connective tissue microfibrils and the microfibrillar part of elastic fibers. The antibodies were of IgM class and were found in 67 of 97 leprosy patients. They occurred in higher titer in patients classified as borderline lepromatous as compared to borderline tuberculoid patients. © 1979.

引用

页码：1 / 8

页数：8

共 19 条

[1]

BEUTNER EH, 1970, AUTOSENSITIZATION PE

[2] IMMUNOHISTOLOGIC ALTERATION OF SKIN AND ULTRASTRUCTURAL CHANGES OF GLOMERULAR BASEMENT-MEMBRANES IN LEPROSY [J].