CONDENSATION OF KETONES WITH DIMETHYL DIMETHYLMALEATE . A SYNTHESIS OF CALYTHRONE

被引:7
作者
ELLIOTT, M
JANES, NF
JEFFS, KA
机构
[1] Department of Insecticides and Fungicides, Rothamsted Experimental Station, Harpenden, Herts
来源
JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 14期
关键词
D O I
10.1039/j39690001845
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Condensation of 4-methylpentan-2-one with dimethyl dimethylmaleate by use of sodium hydride gives calythrone (2-isovaleryl-4,5-dimethylcyclopentene-1,3- dione) (ca. 5%) but the main product is an ester, shown to be methyl 4-isovaleryl-2-methyl-3-oxocyclopentanecarboxylate and not as previously suggested. Reactions with acetone and acetophenone give only the corresponding cyclopentanone derivatives.
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页码:1845 / &
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