GLUCONEOGENESIS IN ISOLATED CHICKEN (GALLUS-DOMESTICUS) LIVER-CELLS

被引：28

作者：

BRADY, LJ ^{[1
]}

ROMSOS, DR ^{[1
]}

LEVEILLE, GA ^{[1
]}

机构：

[1] MICHIGAN STATE UNIV, DEPT FOOD SCI & HUMAN NUTR, E LANSING, MI 48824 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1979年 / 63卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0305-0491(79)90029-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Gluconeogenesis was studied in isolated avian hepatocytes. The highest rate of glucose production obtained was from lactate, followed by dihydroxyacetone, glyceraldehyde, and fructose. Alanine was converted to glucose at only about 4% the rate of lactate. 2. 2. Addition of 10mM sorbitol, xylitol, or ethanol to the hepatocytes increased glucose production from pyruvate 25-40%, while glycerol addition increased it only 9%. 3. 3. Addition of β-hydroxybutyrate had no effect on glucose production from lactate or pyruvate. 4. 4. Addition of octanoate had no effect on glucose production from pyruvate, but depressed it from lactate at 5 mM. 5. 5. Differences in the formation of glucose from various substrates suggest some basic differences in the mode of glucose production between the chick and the rat and guinea-pig. © 1979.

引用

页码：193 / 198

页数：6

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