STEROID-HORMONE RECEPTORS IN THE PROSTATE

被引：29

作者：

KARR, JP ^{[1
]}

WAJSMAN, Z ^{[1
]}

MADAJEWICZ, S ^{[1
]}

KIRDANI, RY ^{[1
]}

MURPHY, GP ^{[1
]}

SANDBERG, AA ^{[1
]}

机构：

[1] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT EXPTL SURG,666 ELM ST,BUFFALO,NY 14263

来源：

JOURNAL OF UROLOGY | 1979年 / 122卷 / 02期

关键词：

D O I：

10.1016/S0022-5347(17)56311-9

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Specific receptors for dihydrotestosterone and estradiol-17-beta have been identified in cytosols of the human and baboon prostate. Binding of radioactive estradiol-17-beta to the 0.4 M potassium chloride extractable component of human prostate nuclei also was demonstrated. Cyproterone acetate and diethylstilbestrol, agents of known high affinity for dihydrotestosterone and estradiol-17-beta receptors, respectively, did not bind significantly to sex hormone binding globulin and, therefore, were useful as competitors in distinguishing of dihydrotestosterone and estradiol-17-beta to sex hormone binding globulin and to their specific receptors. Displacement of [3H]-estradiol-17-beta binding by diethylstilbestrol in cytosols of 11 needle biopsy specimens (mean equals 16.8 mg.) from prostatic cancer patients was analyzed. These preliminary data indicated a trend towards greater competition by diethylstilbestrol for high affinity binding sites in differentiated tumor specimens from men who were not receiving estrogen therapy. Objective and subjective responses to hormone therapy were recorded in these patients, whereas the disease in those men with low displacement assay values progressed.

引用

页码：170 / 175

页数：6

共 20 条

[1]

BASHIRELAHI N, 1976, Urology, V8, P553, DOI 10.1016/0090-4295(76)90516-1

[2] SPECIFIC 17BETA-ESTRADIOL RECEPTOR IN HUMAN BENIGN HYPERTROPHIC PROSTRATE [J].

BASHIRELAHI, N ;

OTOOLE, JH ;

YOUNG, JD .

BIOCHEMICAL MEDICINE, 1976, 15 (03) :254-261

[3] SIMILARITIES BETWEEN "5ALPHA-DIHYDROTESTOSTERONE-RECEPTOR COMPLEXES FROM HUMAN AND RAT PROSTATIC TISSUE - EFFECTS ON RNA-POLYMERASE ACTIVITY [J].

DAVIES, P ;

GRIFFITHS, K .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1975, 3 (02) :143-164

[4] SPECIFIC ESTROGEN RECEPTORS IN LACTATING MAMMARY-GLAND OF RAT [J].

GARDNER, DG ;

WITTLIFF, JL .

BIOCHEMISTRY, 1973, 12 (16) :3090-3096

[5] EVIDENCE FOR A SPECIFIC DIHYDROTESTOSTERONE-BINDING CYTOSOL RECEPTOR IN HUMAN PROSTATE [J].

GELLER, J ;

CANTOR, T ;

ALBERT, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1975, 41 (05) :854-862

[6] STEROID RECEPTORS IN HUMAN PROSTATE .1. ESTRADIOL - 17BETA BINDING IN BENIGN PROSTATIC HYPERTROPHY [J].

HAWKINS, EF ;

NIJS, M ;

BRASSINNE, C ;

TAGNON, HJ .

STEROIDS, 1975, 26 (04) :458-469

[7] STEROID RECEPTORS IN HUMAN PROSTATE - DETECTION OF TISSUE-SPECIFIC ANDROGEN BINDING IN PROSTATE CANCER [J].

HAWKINS, EF ;

NIJS, M ;

BRASSINNE, C .

CLINICA CHIMICA ACTA, 1977, 75 (02) :303-312

[8] STEROID RECEPTORS IN HUMAN PROSTATE .2. SOME PROPERTIES OF ESTROPHILIC MOLECULE OF BENIGN PROSTATIC HYPERTROPHY [J].

HAWKINS, EF ;

NIJS, M ;

BRASSINNE, C .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 70 (03) :854-861

[9] EVALUATION OF VARIOUS METHODS FOR ASSAY OF CYTOPLASMIC ESTROGEN RECEPTORS IN EXTRACTS OF CALF UTERI AND HUMAN BREAST CANCERS [J].

JUNGBLUT, PW ;

HUGHES, S ;

WAGNER, RK ;

HUGHES, A .

ACTA ENDOCRINOLOGICA, 1972, 70 (01) :185-&

[10] ANDROGEN BINDING IN THE BABOON PROSTATE [J].

KARR, JP ;

KIRDANI, RY ;

MURPHY, GP ;

SANDBERG, AA .

ARCHIVES OF ANDROLOGY, 1979, 2 (02) :123-128

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