INTERLEUKIN-4 AS A POTENT INHIBITOR OF BONE-RESORPTION

被引：103

作者：

WATANABE, K

TANAKA, Y

MORIMOTO, I

YAHATA, K

ZEKI, K

FUJIHIRA, T

YAMASHITA, U

ETO, S

机构：

[1] The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Fukuoka, 807, 1-1 Iseigaoka, Yahatanishiku Kitakyushu

[2] The Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Fukuoka, 807, 1-1 Iseigaoka, Yahatanishiku Kitakyushu

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)91550-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A possible role of interleukin-4 (IL-4) in the regulation of bone turnover was assessed by employing a 45Ca prelabeled-fetal mouse long bone culture system. IL-4 inhibited the bone resorption stimulated by parathyroid hormone (PTH), PTH related protein (PTHrP), 1α,25,dihydroxy-vitamine D3[1α,25(OH)2D3], interleukin-1α and -1β (IL-1α, IL-1β) and prostaglandin E2(PGE2). Anti-IL-4 monoclonal antibody abolished the inhibitory effect of IL-4 on the bone resorption. These results suggest that IL-4 may play an important role on the inhibitory regulation of bone resorption. © 1990.

引用

页码：1035 / 1041

页数：7

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